Abstract-

One of the most useful methodologies to create carbon-carbon bonds is the addition of organometallic reagents to carbonyl compounds. The asymmetric version of this reaction allows the generation of a sterocenter and at the same time of an alcohol functionality [1]. However, the use of Grignard reagents in this process has been explored with limited success. As chiral ligands, TADDOL [2] or BINOL [3] derivatives have been reported to be useful for the mentioned transformation, being so far only efficient for the addition to aldehydes. In the last few years we have used ligands of type I for the enantioselective addition of Grignard reagents to aliphatic and aromatic aldehydes and ketones (1) in the presence of titanium tetraisopropoxide to yield chiral alcohols (2) (Scheme) [4,5].