Levine Raphael

Max Born Professor of Natural Philosophy, Emeritus
Ph.D., 1964, Nottingham University
M.Sc., 1960, The Hebrew University of Jerusalem
Office: 
Aronberg 143
Phone: 
02 6585 260
Fax: 
02 6513 742
Research Focus: 

Attophotochemistry

Dynamics of non-equilibrium electronic processes and its optical and chemical probing Information processing by molecular dynamics with special reference to multivalued logic and to parallel operations Molecular devices for logicDissipation and losses in finite rate processes.

Systems chemistry with special application to protein and RNA signaling in health and disease.

Systems biochemistry with special reference to the coupling of biochemical and other cellular processes.

Sensing by chemical recognition Application of the thermodynamics-motivated surprisal analysis away from equilibrium.

Prediction of molecular response to the measured disturbances of single cells and analysis of fluctuations in probing individual cells.

Selected Publications: 

1.  Critical Points in Tumorigenesis: A Carcinogen-Initiated Phase Transition Analyzed via Single-Cell Proteomics. Poovathingal SK, Kravchenko-Balasha N, Shin YS, Levine RD, Heath JR. Small. (2016) Jan 18. doi: 10.1002/smll.201501178. [Epub ahead of print]

2.  Statistical thermodynamics of transcription profiles in normal development and tumorigeneses in cohorts of patients. F. Remacle, R. D. Levine, European Biophys. J. & Biophys. Letts. 44, 709-726 (2015).

3.  Surprisal analysis characterizes the free energy time course of cancer cells undergoing epithelial-to-mesenchymal transition. S. Zadran, R. Arumugam, H. Herschman, M. E. Phelps, R. D. Levine, Proc. Natl. Acad. Sci. US 111, 13235-13240 (2014).

4.  AttoPhotoChemistry. Probing ultrafast electron dynamics by the induced nuclear motion: The prompt and delayed dissociation of N2. B.H. Muskatel, F. Remacle, R.D. Levine, Chem. Phys. Letts 601, 45-48 (2014).

5.  Molecular decision trees realized by ultrafast electronic spectroscopy. B. Fresch, D. Hiluf, E. Collini, R. D. Levine, F. Remacle, Proc. Natl. Acad. Sci. US 110, 17183-17188 (2013).

6.  Free Energy Rhythms in Saccharomyces cerevisiae: A Dynamic Perspective with Implications for Ribosomal Biogenesis. A. Gross, C. M. Li, F. Remacle, R. D. Levine, Biochemistry 52, 1641-1648 (2013).

7.  On a fundamental structure of gene networks in living cells. N. Kravchenko-Balasha, A. Levitzki, A. Goldstein, V. Rotter, A. Gross, F. Remacle, R. D. Levine, Proc. Natl. Acad. Sci. US 109, 4702-4707 (2012).

8.  On the strong and selective isotope effect in the UV excitation of N-2 with implications toward the nebula and Martian atmosphere. B. H. Muskatel, F. Remacle, M. H. Thiemens, R. D. Levine, Proc. Natl. Acad. Sci. US 108, 6020-6025 (2011).

9.  Integrated logic circuits using single-atom transistors. J. A. Mol, J. Verduijn, R. D. Levine, F. Remacle, S. Rogge, Proc. Natl. Acad. Sci. US 108, 13969-13972 (2011).